IHG Rewards Club Members: Get better savings with YOUR RATE. Book hotels direct at holidayinnexpress.com for our lowest rates. You won't find these anywhere else. Stay Your Way at the newest Holiday Inn Express and Suites in St. Charles MO Hotels. Located in charming Historic St. Charles and just 30 miles from downtown St. Louis and the confluence of the Missouri and Mississippi rivers, the Holiday Inn Express® Hotel & Suites St. Charles is the perfect place for people traveling for business or pleasure. While St. Charles has history, charm and quaint parks to entertain you for days, St. Louis is also a hotbed of activity. Our St. Charles hotel is not far from attractions like Six Flags St. Louis, Busch Stadium, Gateway Arch Riverfront and more. Our St. Charles hotel's location is also near the Ameristar and Hollywood Casinos if you wish to try your luck at the slots. When you stay at our hotel in St. Charles, you have easy access to St. Louis and the St. Louis Airport and to several major business corridors. Our St. Charles hotel's 24-hour business center is conveniently equipped with a printer and PC, and our free high-speed Internet access keeps you easily connected. We also have a well-equipped meeting room that can accommodate 30 people, so don't hesitate to take advantage of it. Our hotel in St. Charles is full of great amenities that everyone can enjoy. You can work up a sweat in the 24-hour Fitness Center, swim in the indoor pool, gaze at the lobby aquarium and indulge in a delicious complimentary, hot breakfast bar. Make sure to book a room today to take advantage of everything we offer.